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- Bioss
- bs-3386R-PE
- 2025年10月15日
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100ul
| 产品编号 | bs-3386R-PE |
| 英文名称 | phospho-NR1D1 (Ser55 + Ser59) Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的磷酸化细胞核受体Rev-Erbα抗体 |
| 英文别名 | NR1D1(phospho Ser55+Ser59); NR1D1(phospho S55+S59); EAR-1; EAR1; ERBA-RELATED 1; hRev; Nr1d1; NR1D1_HUMAN; Nuclear Receptor Rev-ErbA alpha; Nuclear receptor subfamily 1 group D member 1; Orphan nuclear receptor NR1D1; Rev erbAalpha; Rev erbalpha; Rev-erbA-alpha; Rev-ErbAalpha; REV-ERBalpha; THRA1; THRAL; Thyroid hormone receptor alpha-like; Thyroid hormone receptor, alpha like; V-erbA related protein EAR-1; V-erbA-related protein 1. |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human REV-ERB alpha around the phosphorylation site of Ser55/59 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Orphan Nuclear Receptors Neuroscience > Endocrine system > Thyroid axis Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚基 | Interacts with C1D and NR2E3. Interacts with SP1. |
| 亚细胞定位 | Nucleus (Potential). |
| 组织特异性 | Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. |
| 相似性 | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| 功能 | Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:100-500} |
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phospho-NR1D1 (Ser55 + Ser59) Rabbit pAb, PE conjugated(bs-3386R-PE)-100ul
￥2980
