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- bs-107500P
- 2026年10月10日
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20ug/50ug/100ug
| 规格： | 20ug | 产品价格： | ￥980.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1880.0 |
| 规格： | 100ug | 产品价格： | ￥2680.0 |
| 产品编号 | bs-107500P |
| 英文名称 | Recombinant HSV1/HHV-1 glycoprotein D/gD Protein, N-His |
| 中文名称 | 重组单纯疱疹病毒糖蛋白D |
| 英文别名 | GD_HHV11; Envelope glycoprotein D; gD; US6; |
| 纯化方法 | AC |
| 理论分子量 | 16.67 kDa |
| 储存液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol |
| 研究领域 | Cancer > Cell cycle > Cell division Cancer > Tumor biomarkers Cell Biology > Cell Cycle > Cell Division > Other cell division antibodies Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis Signal Transduction > Metabolism > Energy Metabolism Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Interacts with human PPP1CA to form a high-molecular-weight complex that dephosphorylates eIF2-alpha. Binds to host PCNA, which may release host cells from growth arrest and facilitate viral replication. |
| 亚细胞定位 | Host cytoplasm. Host nucleus, host nucleolus. Virion. Note=At early times in infection, colocalizes with PCNA and replication proteins in cell nuclei, before accumulating in the cytoplasm by 8 to 12 hours post-infection. The effects on the host cell are mediated by de novo-synthesized ICP34.5, the virion-derived population being either non-functional or present in very low amounts. |
| 相似性 | Belongs to the PPP1R15 family. |
| 功能 | Contributes to HSV resistance to the antiviral effects of alpha/beta interferon. Recruits the serine/threonine-protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, probably through its ability to maintain an environment favorable for viral replication. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell. |
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文献和实验相关实验
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
, 366, 369, 371, 372Mouse Fv heterodimerS, 4 mg/L, α-MF, active564Mouse CC ChemokineS, α-MF, active394Murine endostatinS, 700 mg/L, α-MF170, 510, 515Mouse epidermal growth factorS, 450 mg/L, α-MF[162]Mouse gelatinase BS, 10 mg/L, α-MF[163]Mouse P
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r-HSV1/HHV-1 | HHV-1/HSV-1 | gD Protein, N-His(bs-107500P)-20ug/50ug/100ug
￥980 - 2680
