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| 规格： | 100ug | 产品价格： | ￥2280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 规格： | 20ug | 产品价格： | ￥680.0 |
| 产品编号 | bs-43136P |
| 英文名称 | Recombinant human SAA1 protein, C-hFc (HEK293) |
| 中文名称 | 重组人血清淀粉样蛋白A |
| 英文别名 | amyloid A, serum; Amyloid fibril protein AA; Amyloid protein A; MGC111216; PIG4; SAA; SAA1_HUMAN; Serum amyloid A protein; serum amyloid A-1 protein; serum amyloid A1; TP53I4; Tumor protein p53 inducible protein 4; Recombinant human SAA1 protein, hFc |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 35.5 |
| 浓度 | >0.5mg/ml |
| 储存液 | PBS (pH7.4). |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins > Apolipoproteins Immunology > Innate Immunity > Complement > Regulatory Immunology > Innate Immunity > Cytokines Immunology > Innate Immunity > Macrophage / Inflamm. Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed by the liver; secreted in plasma (at protein level). |
| 翻译后修饰 | This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end. |
| 功能 | Major acute phase reactant. Apolipoprotein of the HDL complex. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012] |
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文献和实验Experimental Applications: Human Acetylcholinesterase as a Model Nervous System Protein
, 5 ng in vitro-transcribed AChE mRNA directed the production of catalytically active recombinant human acetylcholinesterase (rHAChE), at levels of approx 10-fold above background oocyte levels (Table 6 ). Oocyte-produced rHAChE was sensitive to the AChE
Preparation of Recombinant Protein Spotted Arrays for Proteome‐Wide Identification of Kinase Targets
, H. 2009. Profiling the human protein‐DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 139:610‐622. Hudson, J.R., Jr., Dawson, E.P
). After superinfection with helper phage and induction of P lac , Fd (composed of V H and C H 1 domains) and κ-or α-L chains assemble into Fab fragments in the periplasm of the Escherichia coli host strain, and the Fab-ΔpIII protein complex is displayed at one end
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