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- 2025年10月16日
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500ug
| 产品编号 | bs-10160P |
| 英文名称 | Hepcidin-25 Peptide |
| 中文名称 | 铁调节蛋白25多肽 |
| 英文别名 | Hamp; HEPC; HEPC_HUMAN; Hepc20; Hepc25; HEPCIDIN; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor. |
| 中文别名 | 铁调素; 海帕西啶; 肝脏抗菌多肽; 抗菌肽; 铁调节蛋白; |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 理论分子量 | 2.78940 |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. Sequence: Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bonds 7-23, 10-13, 11-19, 14-22) C113H170N34O31S9 MW: 2789.40 CAS: [342790-21-0] |
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文献和实验Characterization of CGRP Receptor Binding
. Poyner, D.R., Andrew, D.P., Brown, D., Bose, C., and Hanley, M.R. 1992. Pharmacological characterization of a receptor for calcitonin gene‐related peptide on rat, L6 myocytes. Br. J. Pharmacol. 105:441‐447
Protein‐Protein Interactions Identified by Pull‐Down Experiments and Mass Spectrometry
(sulfosuccinimidyl) suberate (BS3; see recipe ) Dimethylsulfoxide (DMSO; H 2 O‐free, i.e., fresh) Quenching buffer: 1 M Tris·Cl, pH
/Jenpep2 Functional and quantitative thermodynamic data on peptide binding to immunological biomacromolecules 151. KDBI http://xin.cz3.nus.edu.sg/group/kdbi.asp Kinetic data on biomolecular interactions 152. MHC—Peptide Interaction Database http
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