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- 2025年10月16日
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500ug
| 产品编号 | bs-17329P |
| 英文名称 | TOX4 Antibody Blocking Peptide |
| 中文名称 | TOX4蛋白封闭多肽 |
| 英文别名 | Epidermal Langerhans cell protein LCP1; C14orf92; KIAA0737; LCP1; MIG7; Migration inducing protein 7; TOX 4; TOX high mobility group box family member 4; Tox4; TOX4_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding |
| 亚基 | Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS. {ECO:0000269|PubMed:20516061}. |
| 亚细胞定位 | Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated with chromatin. |
| 相似性 | Contains 1 HMG box DNA-binding domain. |
| 功能 | Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:20516061}. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TOX high mobility group box family member 4 (TOX4), also known as epidermal Langerhans cell protein 1 (LCP1), is a 621 amino acid protein that localizes to the nucleus. Mapping to chromosome 14q11.2, TOX4 contains one high mobility group (HMG) box DNA-binding domain, corresponding to amino acids 223 to 291 of human TOX4. The HMG box domain is a region of about 80 amino acids with unusual DNA binding preferences. HMG proteins bind DNA without sequence specificity. Furthermore, they bind to distorted or modified DNA and have the property to bend DNA. The presence of the HMG box DNA-binding domain suggests that TOX4 plays a role in transcriptional regulation. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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