- ￥880
- Bioss
- bs-12144P
- 2025年10月16日
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500ug
| 产品编号 | bs-12144P |
| 英文名称 | SHC2 Antibody Blocking Peptide |
| 中文名称 | SCK蛋白封闭多肽 |
| 英文别名 | Sck; Protein Sck; SCK; SH2 domain protein C2; SHC transforming protein 2; SHCB; Src homology 2 domain containing transforming protein C2; SHC2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Intracellular Signaling > Adapters |
| 亚基 | Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. |
| 组织特异性 | Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. |
| 翻译后修饰 | Phosphorylated on tyrosines by the Trk receptors. |
| 相似性 | Contains 1 PID domain.
Contains 1 SH2 domain. |
| 功能 | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8). |
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SHC2 Antibody Blocking Peptide(bs-12144P)-500ug
￥880
