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- bs-3339P
- 2025年10月16日
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500ug
| 产品编号 | bs-3339P |
| 英文名称 | Phospho-PLCG2 (Tyr759) Antibody Blocking Peptide |
| 中文名称 | 磷酸化磷酯酶Cγ2封闭多肽 |
| 英文别名 | PLCG 2 (phospho Y759); PLCG 2 (phospho Tyr759); ; PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol specific); PLCG2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Hydrolysis Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Hydrolysis Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > Lipid Signaling > PLC |
| 亚基 | Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) . |
| 翻译后修饰 | Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
| 相似性 | Contains 1 C2 domain. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Contains 2 SH2 domains. Contains 1 SH3 domain. |
| 功能 | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. |
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Phospho-PLCG2 (Tyr759) Antibody Blocking Peptide(bs-3339P)-500ug
￥1080
