- ￥880
- Bioss
- bs-16240P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16240P |
| 英文名称 | Germinal Center Kinase Antibody Blocking Peptide |
| 中文名称 | 生发中心激酶MAP4K2封闭多肽 |
| 英文别名 | GC kinase; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; GC kinase; GCK; Germinal center kinase; germinal centre kinase (GC kinase); M4K2_HUMAN; MAP4K2; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Mitogen activated protein kinase kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase kinase 2; Rab8 interacting protein; Rab8 interacting protein, formerly; Rab8-interacting protein; RAB8IP; RAB8IP, formerly. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚细胞定位 | Cytoplasm. Basolateral cell membrane. Golgi apparatus membrane. |
| 组织特异性 | Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. |
| 相似性 | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain. |
| 功能 | Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008] |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Identification of a Mutant Kinase/ATP Analog Pair
enough to interact with the ATP-binding site of the kinase but is unable to be used by the kinase as an ATP source and is therefore simply blocking [y-32 P]ATP from the ATP-binding site. To distinguish between these, it is necessary to directly test the ability
Synthesis and Probing of Membrane-bound Peptide Arrays
Synthesis and Probing of Membrane-bound Peptide Arrays Ronald Frank Department of Chemical Biology, GBF (German Research Center for Biotechnology), 38124 Braunschweig, Germany
同位素法测定底物磷酸化活性方法 Phosphorylation of Substrates
identification of kinase-associated substrates by immunoprecipitating a tagged form of the mutant kinase from transfected COS-1 cells and performing a kinase reaction by the addition of [γ-32 P]ATP analog. The second approach involves the addition of recombinant
技术资料暂无技术资料 索取技术资料
