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- 技术资料
- 规格:
500ug
| 产品编号 | bs-14571P |
| 英文名称 | ELOVL1 Antibody Blocking Peptide |
| 中文名称 | ELOVL1蛋白封闭多肽 |
| 英文别名 | 3 keto acyl CoA synthase ELOVL1; 3-keto acyl-CoA synthase ELOVL1; CGI 88; Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 1; Elongation of very long chain fatty acids like 1; Elongation of very long chain fatty acids protein 1; ELOV1_HUMAN; ELOVL 1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; ELOVL1; Ssc1; very long chain 3 oxoacyl CoA synthase 1; Very-long-chain 3-oxoacyl-CoA synthase 1. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Synthesis Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Interacts with LASS2, TECR and HSD17B12. |
| 亚细胞定位 | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the ELO family. |
| 功能 | Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Elongation of very long chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acids protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acids of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism. |
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ELOVL1 | SSC1 Ab Blocking Peptide(bs-14571P)-500ug
¥880










