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- Bioss
- bs-0402P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-0402P |
| 英文名称 | Bri3bp Antibody Blocking Peptide |
| 中文名称 | 宫颈癌原基因1/bri3结合蛋白封闭多肽 |
| 英文别名 | BRI3-binding protein; HCCR-1; HCCR1; HCCRBP-1; I3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; I3-binding protein; BRI3B_HUMAN; BRI3BP. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚基 | Interacts with LETMD1. |
| 亚细胞定位 | Mitochondrion outer membrane; Multi-pass membrane protein (Probable). |
| 组织特异性 | Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas. |
| 功能 | Involved in tumorigenesis and may function by stabilizing p53/TP53. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | BRI3BP is a 251 amino acid multi-pass membrane protein. Though widely expressed, BRI3BP is found at highest levels in brain, kidney and liver where it localizes to the endoplasmic reticulum (ER) and is involved in ER structural dynamics and mitochondrial viability. Possessing pro-apoptotic properties and the ability to potentiate drug-induced apoptosis, BRI3BP overexpression has been shown to enhance caspase-3 and mitochondrial cytochrome c release in etoposide-treated human embryonic kidney 293T cells. The gene encoding BRI3BP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. |
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Bri3bp Antibody Blocking Peptide(bs-0402P)-500ug
￥880
