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- 2025年10月16日
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| 规格： | 10ug | 产品价格： | ￥2080.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥6800.0 |
| 规格： | 500ug | 产品价格： | ￥28000.0 |
| 产品编号 | bs-48016P |
| 英文名称 | Recombinant human BMP-4 protein (Active, HEK293) |
| 中文名称 | 重组人骨形态发生蛋白-4 (活性的, Tag free) |
| 英文别名 | rhBMP-4; BMP 4; BMP2B; BMP2B1; Bone morphogenetic protein 4; DVR4; ZYME; BMP4_HUMAN; BMP-4; Bone morphogenetic protein 2B; BMP-2B. ;Recombinant human BMP-4 protein (Active, HEK293) |
| 中文别名 | 人骨形态发生蛋白-4重组蛋白; 重组人骨形态发生蛋白-4; 人重组骨形态发生蛋白-4; 重组人BMP4; |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 实际分子量 | 34-40 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | Lyophilized from 0.22um filtered solution in PBS (pH7.4) with 5mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. |
| 研究领域 | Cancer > Growth factors > TGF Cardiovascular > Angiogenesis > Growth Factors > TGF Developmental Biology > Organogenesis > Excretory system development > Kidney development Developmental Biology > Organogenesis > Gut development > Gut specification Developmental Biology > Organogenesis > Nervous system development Signal Transduction > Growth Factors/Hormones > TGF Stem Cells > Signaling Pathways > TGF beta > Secreted |
| 亚基 | Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix. |
| 组织特异性 | Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. |
| 相似性 | Belongs to the TGF-beta family. |
| 功能 | Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after reconstitution. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix. |
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