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CRX1 Antibody Blocking Peptide

(bs-3798P)-500ug
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  • bs-3798P
  • 2025年10月16日
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      500ug

    产品编号bs-3798P
    英文名称CRX1 Antibody Blocking Peptide
    中文名称CRX封闭多肽
    英文别名Crx; Crx-1; Crx 1; CRD; LCA7; CRX_HUMAN.
    纯化方法HPLC
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Neuroscience > Sensory System > Visual system

    亚基Interacts with SCA7. Interacts with RAX2. Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC.
    亚细胞定位Nucleus.
    组织特异性Retina.
    相似性Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain.
    功能Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].

     

     

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