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- bs-13701P
- 2025年10月16日
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500ug
| 产品编号 | bs-13701P |
| 英文名称 | SIT Antibody Blocking Peptide |
| 中文名称 | 跨膜接头蛋白SIT封闭多肽 |
| 英文别名 | gp30/40; SHP intracting transmembrane adapter protein; SHP2-interacting transmembrane adapter protein; Signaling threshold-regulating transmembrane adapter 1; SIT; Sit1; SIT1_HUMAN; Suppression inducing transmembrane adapter 1; Suppression-inducing transmembrane adapter 1. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. |
| 翻译后修饰 | Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. |
| 功能 | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Polyclonal Antibody Production
or cloned and expressed as a fusion protein with a larger protein. If it is a peptide or small molecule, a carrier-hapten conjugate must be made. Purify your antigen well to obtain antibodies with good specificity. Obtain at least two 6 week old New
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
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