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- bs-8613P
- 2025年10月16日
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500ug
| 产品编号 | bs-8613P |
| 英文名称 | Complement C2/C2/Complement C2a fragment Antibody Blocking Peptide |
| 中文名称 | 补体C2封闭多肽 |
| 英文别名 | Complement C2; Complement component 2; Complement factor 2; Complement C2a fragment; CO2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Complement > Classical Pathway |
| 亚基 | C2a interacts with Schistosoma haematobium TOR (viaN-terminal extracellular domain). This results in inhibition of theclassical and lectin pathway of complement activation, probably dueto interference with binding of C2a to C4b such that C3 convertasecannot be formed. This infers resistance to complement-mediatedcell lysis, allowing parasite survival and infection. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain. Contains 3 Sushi (CCP/SCR) domains. Contains 1 VWFA domain. |
| 功能 | Component C2 which is part of the classical pathway ofthe complement system is cleaved by activated factor C1 into twofragments: C2b and C2a. C2a, a serine protease, then combines withcomplement factor 4b to generate the C3 or C5 convertase. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-10482P is one synthetic peptide derived from human C2a. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]. |
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文献和实验Determination of Antibody Glycosylation by Mass Spectrometry
cytotoxicity and complement-dependent cytotoxicity (CDC). The carbohydrate moieties can vary strongly depending on the production host and can be manipulated by different fermentation conditions, thereby influencing the function of the antibody
【翻译】Development trends for monoclonal antibody cancer therapeutics
, after binding to a target, mAbs can recruit effector cells such as natural killer cells, macrophages or neutrophils, or activate complement to destroy the target3, 24, 25, 26, 27. These two modes of action are referred to as antibody-dependent cell cytotoxicity
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
, 12 mg/L, α-MF or endogenous signal507Porcine pepsinogenS, PHO, 30 mg/L, active504Rabbit intestinal peptide transporter (PepT1)I[177]Rabbit intestinal peptide transporter (PEPT2)I[178]Rabbit antibody: monoclonal single-chain Fv specific for recombinant
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