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500ug
| 产品编号 | bs-11983P |
| 英文名称 | CACNB4/L-type Ca++ CPβ4 Antibody Blocking Peptide |
| 中文名称 | L型电压依赖型钙通道β4封闭多肽 |
| 英文别名 | CAB4; L-type Ca++ CPβ4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4; Voltage-dependent L-type calcium channel subunit beta-4. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG. |
| 组织特异性 | Expressed predominantly in the cerebellum and kidney. |
| 相似性 | Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. |
| 功能 | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events. |
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文献和实验Synthesis and Probing of Membrane-bound Peptide Arrays
can be made. For the introduction of randomized X positions in the peptide sequences, take the appropriate Fmoc-AA-mix stock solution from the freezer, bring to room temperature, and activate by adding DIC (1.5 µl per 100 µl-vial
. Y., and Yao, S. Q. (2002) Antibody-based fluorescence detection of kinase activity on a peptide array. Bioorg.Med. Chem. Lett. 1 2 , 2085-2088. 7. Fukunaga, R. and Hunter, T. (1997) M N K 1 , a n e w M A P kinase-activated protein kinase
PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells
above. The epitope of some antibodies is not yet identified, an example being the rat type I cell-specific antibody, VIIIB2. Type I cells are also reported to express carbopeptidase membrane-bound enzyme (CP-M), intercellular adhesion molecule-1 (ICAM-1), &beta
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