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- bs-17406P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-17406P |
| 英文名称 | phospho-HIRA (Thr555) Antibody Blocking Peptide |
| 中文名称 | 磷酸化HIRA蛋白封闭多肽 |
| 英文别名 | HIRA (phospho T555); p-HIRA (phospho T555); DGCR1; DGGR 1; DGGR1; DiGeorge critical region gene 1; HIR; HIR histone cell cycle regulation defective homolog A; HIRA; HIRA protein; HIRA_HUMAN; Protein HIRA; TUP 1; TUP1; TUP1 like enhancer of split protein 1; TUP1-like enhancer of split protein 1; TUPLE 1; TUPLE1. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Reproduction > Germ cell markers Epigenetics and Nuclear Signaling > Chromatin Remodeling > Histone chaperones Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > RNAi Epigenetics and Nuclear Signaling > RNAi > Argonaute and Piwi Epigenetics and Nuclear Signaling > RNAi > RISC Stem Cells > Germline Stem Cells > Embryonic Germ Cells |
| 亚基 | Interacts with histone H3F3B, PAX3 and PAX7 (By similarity). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1. |
| 亚细胞定位 | Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence. |
| 组织特异性 | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
| 翻译后修饰 | Sumoylated. Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo. |
| 相似性 | Belongs to the WD repeat HIR1 family. Contains 8 WD repeats. |
| 功能 | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008] |
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phospho-HIRA (Thr555) Antibody Blocking Peptide(bs-17406P)-500ug
￥1080
