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- 2025年10月16日
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500ug
| 产品编号 | bs-12183P |
| 英文名称 | Kv1.4 Antibody Blocking Peptide |
| 中文名称 | 电压门控性钾通道蛋白Kv1.4封闭多肽 |
| 英文别名 | Voltage gated K+ channel HuKII; cardiac potassium channel; fetal skeletal muscle potassium channel; HBK 4; HBK4; HK 1; HK1; HPCN 2; HPCN2; HUK II; HUKII; KCNA 4; KCNA 8; KCNA4; KCNA4_HUMAN; KCNA4L; KCNA8; kv1.4; PCN 2; PCN2; potassium channel 2; potassium channel KCNA4; potassium channel protein; Potassium voltage gated channel shaker related subfamily member 4; Potassium voltage gated channel subfamily A member 4; potassium voltage-gated channel shaker-related subfamily member 4-like; Potassium voltage-gated channel subfamily A member 4; rapidly inactivating potassium channel; Shaker related potassium channel Kv1.4; shaker-related potassium channel Kv1.4; type A potassium channel; Voltage gated potassium channel HBK4; Voltage gated potassium channel HK1; Voltage gated potassium channel subunit Kv1.4; Voltage-gated K(+) channel HuKII; voltage-gated potassium channel; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; voltage-gated potassium channel protein Kv1.4; Voltage-gated potassium channel subunit Kv1.4. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Potassium Channels |
| 亚基 | Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with SIGMAR1 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity). |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the potassium channel family.
A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. |
| 功能 | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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