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- IHC0612
- 2025年10月15日
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50T
| 产品编号 | IHC0612 |
| 英文名称 | ABCE1 Ready-To-Use IHC Kit |
| 中文名称 | ABCE1即用型免疫组化试剂盒 |
| 英文别名 | ABC38; ABCE1; C79080; OABP; OK/SW-cl.40; RLI; RLI1; RNASEL1; RNASELI; RNS41; RNS4I |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 亚基 | (Microbial infection) Interacts with Chandipura virus matrix protein. Interacts with PINK1 (PubMed:29861391). Interacts with CNOT4 (PubMed:29861391). Interacts with PELO (PubMed:29861391). Probably heterodimerizes with RNASEL; this interaction inhibits RNASEL (Probable) (PubMed:9660177). (Microbial infection) Interacts with HIV-1 proteins Vif and Gag. (Microbial infection) Interacts with HIV-2 protein Gag. |
| 亚细胞定位 | #Cytoplasm #Mitochondrion |
| 翻译后修饰 | Ubiquitinated by CNOT4 (PubMed:29861391). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (PubMed:29861391). |
| 相似性 | Belongs to the ABC transporter superfamily. ABCE family. |
| 功能 | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Rat testis tissue slide using IHC0612 (ABCE1 Kit).
Immunohistochemical analysis of paraffin embedded Human breast cancer tissue slide using IHC0612 (ABCE1 Kit).
Immunohistochemical analysis of paraffin embedded Mouse testis tissue slide using IHC0612 (ABCE1 Kit).
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ABCE1 Ready-To-Use IHC Kit(IHC0612)-50T
￥3200
