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- IHC0590
- 2025年10月15日
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50T
| 产品编号 | IHC0590 |
| 英文名称 | PGAM1 Ready-To-Use IHC Kit |
| 中文名称 | PGAM1即用型免疫组化试剂盒 |
| 英文别名 | 2310050F24Rik; CDABP0006; HEL-S-35; Pgam-1; PGAM-B; PGAM1; PGAMA; BPG dependent PGAM 1; BPG dependent PGAM1; BPG-dependent PGAM 1 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 亚基 | Homodimer. |
| 组织特异性 | Expressed in the liver and brain. Not found in the muscle. |
| 翻译后修饰 | Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme. |
| 相似性 | Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. |
| 功能 | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202) |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | PGAM1 belongs to the phosphoglycerate mutase family. PGAM1 is an important component of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM1 protein is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). Mutations in PGAM1 cause muscle phosphoglycerate mutase efficiency, also known as glycogen storage disease X. Recombinant human PGAM protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Rat testis tissue slide using IHC0590 (PGAM1 Kit).
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue slide using IHC0590 (PGAM1 Kit).
Immunohistochemical analysis of paraffin embedded Human testis tissue slide using IHC0590 (PGAM1 Kit).
Immunohistochemical analysis of paraffin embedded Mouse testis tissue slide using IHC0590 (PGAM1 Kit).
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PGAM1 Ready-To-Use IHC Kit(IHC0590)-50T
￥3200
