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- IHC0587
- 2025年10月15日
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50T
| 产品编号 | IHC0587 |
| 英文名称 | GCS beta 1 Ready-To-Use IHC Kit |
| 中文名称 | 鸟苷酸环化酶β1即用型免疫组化试剂盒 |
| 英文别名 | GC-S-beta-1; GC-SB3; GCbeta1; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3; SGC; GCS-beta-1; GCS-beta-3 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 亚基 | The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1 (PubMed:1352257, PubMed:23505436, PubMed:24669844). Can also form inactive homodimers in vitro (PubMed:23505436, PubMed:24669844). |
| 亚细胞定位 | Cytoplasm |
| 组织特异性 | Detected in brain cortex and cerebellum (at protein level). |
| 相似性 | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| 功能 | Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Rat brain tissue slide using IHC0587 (GCS beta 1 Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0587 (GCS beta 1 Kit).
Immunohistochemical analysis of paraffin embedded Human heart tissue slide using IHC0587 (GCS beta 1 Kit).
Immunohistochemical analysis of paraffin embedded Mouse brain tissue slide using IHC0587 (GCS beta 1 Kit).
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GCS beta 1 Ready-To-Use IHC Kit(IHC0587)-50T
￥3200
