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- IHC0580R
- 2025年10月15日
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50T
| 产品编号 | IHC0580R |
| 英文名称 | Rat LRP/MVP Ready-To-Use IHC Kit |
| 中文名称 | 大鼠肺耐药相关蛋白即用型免疫组化试剂盒 |
| 英文别名 | LRP; MVP; VAULT1; 2310009M24Rik; Lung Resistance Related Protein |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Rat |
| 亚基 | The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540. |
| 亚细胞定位 | #Cytoplasm #Nuclear pore complex #Nucleus |
| 组织特异性 | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| 翻译后修饰 | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| 功能 | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Rat colon tissue slide using IHC0580R (Rat LRP/MVP Kit).
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Rat LRP/MVP Ready-To-Use IHC Kit(IHC0580R)-50T
￥3200
