- ￥3200
- Bioss
- IHC0545
- 2025年10月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
50T
| 产品编号 | IHC0545 |
| 英文名称 | Thymidylate synthase Ready-To-Use IHC Kit |
| 中文名称 | 胸苷酸合成酶即用型免疫组化试剂盒 |
| 英文别名 | HST422; OK/SW-cl.29; TMS; TS; TYMS |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 亚基 | Homodimer. |
| 亚细胞定位 | #Cytoplasm #Membrane #Mitochondrion #Mitochondrion inner membrane #Nucleus |
| 功能 | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Human esophageal cancer tissue slide using IHC0545 (Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Mouse spleen tissue slide using IHC0545 (Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Rat spleen tissue slide using IHC0545 (Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Human spleen tissue slide using IHC0545 (Thymidylate synthase Kit).
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Thymidylate synthase Ready-To-Use IHC Kit(IHC0545)-50T
￥3200
