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- IHC0528R
- 2025年10月15日
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- 规格：
50T
| 产品编号 | IHC0528R |
| 英文名称 | Rat GAD65 Ready-To-Use IHC Kit |
| 中文名称 | 大鼠谷氨酸脱羧酶-65即用型免疫组化试剂盒 |
| 英文别名 | 6330404F12Rik; GAD(65); Gad-2; GAD2; GAD65 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Rat |
| 亚基 | Homodimer. Interacts with SAR1A. |
| 亚细胞定位 | #Cell membrane #Cell projection #Cytoplasm #Cytoplasmic vesicle #Golgi apparatus #Membrane #Synapse |
| 翻译后修饰 | Phosphorylated; which does not affect kinetic parameters or subcellular location.By Similarity Palmitoylated; which is required for presynaptic clustering. |
| 相似性 | Belongs to the group II decarboxylase family. |
| 功能 | Catalyzes the production of GABA. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Rat brain tissue slide using IHC0528R (Rat GAD65 Kit).
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Rat GAD65 Ready-To-Use IHC Kit(IHC0528R)-50T
￥3200
