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- IHC0442M
- 2025年10月15日
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50T
| 产品编号 | IHC0442M |
| 英文名称 | Mouse PON1 Ready-To-Use IHC Kit |
| 中文名称 | 小鼠芳香酯酶1(对氧磷酶)即用型免疫组化试剂盒 |
| 英文别名 | PON1; A esterase 1; A-esterase 1; Aromatic esterase 1; Arylesterase B type; ESA; Esterase A; K 45; K-45; MVCD5; Paraoxonase 1; Paraoxonase; Paraoxonase B type; Paraoxonase1; PON 1; PON; PON-1; PON1_HUMAN; Serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Mouse |
| 亚基 | Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU. |
| 亚细胞定位 | #HDL #Secreted |
| 组织特异性 | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
| 翻译后修饰 | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
| 相似性 | Belongs to the paraoxonase family. |
| 功能 | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded mouse liver tissue slide using IHC0442M (Mouse PON1 IHC Kit).
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Mouse PON1 Ready-To-Use IHC Kit(IHC0442M)-50T
￥3200
