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- IHC0358
- 2025年10月15日
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50T
| 产品编号 | IHC0358 |
| 英文名称 | WT1 Ready-To-Use IHC Kit |
| 中文名称 | 肾母细胞瘤蛋白即用型免疫组化试剂盒 |
| 英文别名 | AWT1; D630046I19Rik; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; Wt-1; WT1; WT33; Wilms tumor 1 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse |
| 亚基 | Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2 (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with AMER1. Interacts with RBM4 |
| 亚细胞定位 | #Cytoplasm #Nucleus |
| 组织特异性 | Expressed in the kidney and a subset of hematopoietic cells. |
| 相似性 | Belongs to the EGR C2H2-type zinc-finger protein family. |
| 功能 | Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | The Wilms Tumor 1 gene encodes one of the WPP domain-interacting proteins (Wilms Tumor 1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). Wilms Tumor 1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0358 (WT1 Kit).
Immunohistochemical analysis of paraffin embedded mouse kidney tissue slide using IHC0358 (WT1 Kit).
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WT1 Ready-To-Use IHC Kit(IHC0358)-50T
￥3200
