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- IHC0269
- 2025年10月15日
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50T
| 产品编号 | IHC0269 |
| 英文名称 | NSE Ready-To-Use IHC Kit |
| 中文名称 | 神经元特异性烯醇化酶即用型免疫组化试剂盒 |
| 英文别名 | AI837106; D6Ertd375e; Eno-2; ENO2; HEL-S-279; NSE; RNEN3; Enolase 2; Neuron specific gamma enolase |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 亚基 | Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. |
| 亚细胞定位 | Cell membrane Cytoplasm Membrane |
| 组织特异性 | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| 相似性 | Belongs to the enolase family. |
| 功能 | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured.NSE is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The alpha-subunit is expressed in most tissues, the beta-subunit only in muscle, and the gamma-subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to NSE protein are useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Further, NSE is found in elevated concentrations in plasma and certain neoplasias that include pediatric neuroblastoma and small cell lung cancer. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded rat cerebellum tissue slide using IHC0269 (NSE IHC Kit).
Immunohistochemical analysis of paraffin embedded human cerebellum tissue slide using IHC0269 (NSE IHC Kit).
Immunohistochemical analysis of paraffin embedded mouse cerebellum tissue slide using IHC0269 (NSE IHC Kit).
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NSE Ready-To-Use IHC Kit(IHC0269)-50T
￥3200
