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- IHC0251M
- 2025年10月15日
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50T
| 产品编号 | IHC0251M |
| 英文名称 | Mouse Frizzled 5 Ready-To-Use IHC Kit |
| 中文名称 | 小鼠Wnt信号受体蛋白即用型免疫组化试剂盒 |
| 英文别名 | 5330434N09Rik; AI427138; C2orf31; Frizzled-5; Fz-5; Fz5; FZD5; HFZ5; I79_014467; mFz5; DKFZP434E2135; Frizzled homolog 5; Frizzled5; Fz 5; FZD 5; hFz5; FZD5_HUMAN; FzE 5; FzE5; HFZ 5; MGC129692; Seven transmembrane receptor frizzled 5; Uncharacterized protein C2orf31; Wnt receptor |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Mouse |
| 亚基 | Binding of unsaturated fatty acid molecules (via FZ domain) promotes homodimerization (PubMed:28377511). Interacts with WNT2B (PubMed:12490564). Interacts with WNT3A (PubMed:26908622). Interacts with WNT7A (PubMed:18230341, PubMed:20530549, PubMed:26908622). Interacts with GOPC (By similarity). |
| 亚细胞定位 | Cell membrane Cell projection Golgi apparatus Membrane Synapse |
| 翻译后修饰 | Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. |
| 相似性 | Belongs to the G-protein coupled receptor Fz/Smo family. |
| 功能 | Receptor for Wnt proteins (PubMed:10097073, PubMed:20530549, PubMed:26908622, PubMed:9054360). Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (PubMed:26908622). |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded mouse colon tissue slide using IHC0251M (Mouse Frizzled 5 IHC Kit).
Immunohistochemical analysis of paraffin embedded mouse brain tissue slide using IHC0251M (Mouse Frizzled 5 IHC Kit).
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Mouse Frizzled 5 Ready-To-Use IHC Kit(IHC0251M)-50T
￥3200
