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- IHC0237R
- 2025年10月15日
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- 详细信息
- 技术资料
- 规格：
50T
| 产品编号 | IHC0237R |
| 英文名称 | Rat CD13 Ready-To-Use IHC Kit |
| 中文名称 | 大鼠CD13即用型免疫组化试剂盒 |
| 英文别名 | ANPEP; AP-M; AP-N; APN; CD13; GP150; Lap-1; LAP1; P150; PEPN |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Rat |
| 亚基 | Homodimer. Interacts with SLC6A19 (By similarity). (Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein. |
| 亚细胞定位 | Cell membrane Membrane |
| 组织特异性 | Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients. |
| 翻译后修饰 | Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form. |
| 相似性 | Belongs to the peptidase M1 family. |
| 功能 | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD13 (ANPEP) is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. CD13 is a metalloprotease that preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 also has a role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is expressed by granulocytes, monocytes, myeloid leukemia cells, and is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions as an aminopeptidase enzyme and is also alpha receptor for coronavirus. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded rat liver tissue slide using IHC0237R (Rat CD13 IHC Kit).
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Rat CD13 Ready-To-Use IHC Kit(IHC0237R)-50T
￥3200
