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- bs-16063R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-16063R-BF350 |
| 英文名称 | FCP1 Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的FCP1蛋白抗体 |
| 英文别名 | CCFDN; CTD(carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; CTD of POLR2A, phosphatase of, subunit 1; CTDP1; CTDP1_HUMAN; EC 3.1.3.16; RNA polymerase II subunit A C terminal domain phosphatase; RNA polymerase II subunit A C-terminal domain phosphatase; Serine phosphatase FCP1a; TFIIF associating CTD phosphatase; TFIIF-associating CTD phosphatase 1; TFIIF-associating CTD phosphatase; Transcription factor IIF-associating CTD phosphatase 1. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FCP1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription Epigenetics and Nuclear Signaling > Transcription > RNA polymerase Signal Transduction > Protein Phosphorylation > Ser / Thr Phosphatases |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitously expressed. Isoform 3 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and placenta. |
| 翻译后修饰 | Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1. |
| 相似性 | Contains 1 BRCT domain. _x000D_ Contains 1 FCP1 homology domain. |
| 功能 | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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FCP1 Rabbit pAb, BF350 conjugated(bs-16063R-BF350)-100ul
￥2980
