- ￥2980
- Bioss
- bs-3317R-APC
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
phospho-TAK1 (Thr187) Rabbit pAb, Biotin conjugated(bs-3438R-Bio)-100ul
￥2980Tuberin Rabbit pAb, PE-Cy7 conjugated(bs-3586R-PE-Cy7)-100ul
￥2980
C8orf55 Rabbit pAb, BF350 conjugated(bs-15296R-BF350)-100ul
￥2980
Kir2.1 Rabbit pAb, PE-Cy5.5 conjugated(bs-17067R-PE-Cy5.5)-100ul
￥2980
Kv4.2 Rabbit pAb, BF647 conjugated(bs-9442R-BF647)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-3317R-APC |
| 英文名称 | phospho-PAK2 (Ser20) Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的磷酸化p21激活激酶2抗体 |
| 英文别名 | PAK2(phospho S20); PAK2(phospho Ser20); p-PAK2(S20); p-PAK2(Ser20); CB422; EC 2.7.11.1; gamma PAK; hPAK65; Kinase; p21(CDKN1A)-activated kinase 2a; p21 activated kinase 2; p21 protein(Cdc42/Rac)-activated kinase 2; p21 protein Cdc42 Rac activated kinase 2; p21-activated kinase, 65-KD antibody p21-activated protein kinase I; p21CDKN1A activated kinase 2; p58; p65PAK; PAK 2; PAK65; PAKgamma; S6 H4 kinase; Serine threonine protein kinase PAK 2. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human PAK2 around the phosphorylation site of Ser20 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases Cell Biology > Apoptosis > Intracellular > Kinases Microbiology > Interspecies Interaction > Host Virus Interaction Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10. |
| 亚细胞定位 | Cytoplasm and Nucleus. Cytoplasm > perinuclear region. Membrane. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. |
| 组织特异性 | Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. |
| 翻译后修饰 | Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate. _x000D_ During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34. _x000D_ Ubiquitinated, leading to its proteasomal degradation. _x000D_ PAK-2p34 is myristoylated. |
| 相似性 | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. _x000D_ Contains 1 CRIB domain. _x000D_ Contains 1 protein kinase domain. |
| 功能 | The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验嗨，大家好，我是抗癌药物，你们对我一定都不陌生。大多数人都不想跟我有关系吧，谁让我的「对手」——癌细胞那么可怕呢。不过我可是大家的好朋友，有句古话说得好：「良药苦口利于病」，我其实是帮助病人尽快战胜疾病的。 新闻报道中，时常有我的身影，可大多并不是我的真正模样。所以今天我就出来见见面、聊聊天，让大家认识一个真实的我。 据WHO统计，每年约820万人死于我的天敌，预计占全球死亡人数的13%；同时，WHO预测，未来20年，癌症病例将增加70
Generation of Dendritic Cells from Lymphoid Precursors
Dendritic cells (DC) are “professional” antigen presenting cells (APC) that are pivotal for the initiation of T-cell-dependent immune responses (1 ). DC are widely distributed cells in the body, but are scarce and thus difficult to purify
技术资料暂无技术资料 索取技术资料
