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- Bioss
- bs-3601R-BF488
- 2025年09月30日
- 产品信息以Bioss网站为准
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100ul
| 产品编号 | bs-3601R-BF488 |
| 英文名称 | MTF-1 Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的金属应答元件结合转录因子-1抗体 |
| 英文别名 | Metal regulatory transcription factor 1; Metal response element binding transcription factor 1; MRE binding transcription factor; Transcription factor MTF1; MTF1_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MTF-1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 6 C2H2-type zinc fingers. |
| 功能 | Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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MTF-1 Rabbit pAb, BF488 conjugated(bs-3601R-BF488)-100ul
￥2980
