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- Bioss
- bs-9474R-AE
- 2025年09月30日
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100ul
| 产品编号 | bs-9474R-AE |
| 英文名称 | phospho-NFAT5 (Ser1197) Rabbit pAb, AE conjugated |
| 中文名称 | AE标记的磷酸化活化T细胞核因子5蛋白抗体 |
| 英文别名 | NFAT5(phospho S1197); p-NFAT5(phospho S1197); Glutamine rich protein H65; KIAA0827; NF AT5; NF-AT5; NFAT 5; NFAT L1; NFAT like protein 1; NFAT5; NFAT5_HUMAN; NFATL 1; NFATL1; NFATZ; Nuclear factor of activated T cells 5; Nuclear factor of activated T cells 5 tonicity responsive; Nuclear factor of activated T cells; Nuclear factor of activated T-cells 5; OREBP; Osmotic response element binding protein; T cell transcription factor NFAT 5; T cell transcription factor NFAT5; T-cell transcription factor NFAT5; TonE binding protein; TonE-binding protein; TonEBP; Tonicity responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein. |
| 产品应用 | ELISA=1:500-5000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFATs Epigenetics and Nuclear Signaling > Transcription > Other factors Immunology > Adaptive Immunity > T Cells > Non-CD Signal Transduction > Signaling Pathway > Nuclear Signaling > NFATS |
| 亚基 | Homodimer when bound to DNA, completely encircles its DNA target. Does not bind with Fos and Jun transcription factors. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. |
| 翻译后修饰 | Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization. |
| 相似性 | Contains 1 RHD (Rel-like) domain. |
| 功能 | Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:500-5000} |
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phospho-NFAT5 (Ser1197) Rabbit pAb, AE conjugated(bs-9474R-AE)-100ul
￥2980
