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- bs-19003R-BF488
- 2025年09月30日
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100ul
| 产品编号 | bs-19003R-BF488 |
| 英文名称 | NAGPA Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的NAGPA蛋白抗体 |
| 英文别名 | Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA_HUMAN; phosphodiester alpha-GlcNAcase. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NAGPA |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Homotetramer arranged as two disulfide-linked homodimers |
| 亚细胞定位 | Golgi apparatus > Golgi stack membrane. Cis/medial Golgi. |
| 组织特异性 | Isoform 2 may be brain-specific. |
| 翻译后修饰 | The precursor is cleaved and activated in the trans-Golgi network by a furin endopeptidase. |
| 相似性 | Contains 1 EGF-like domain._x000D_ |
| 功能 | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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NAGPA Rabbit pAb, BF488 conjugated(bs-19003R-BF488)-100ul
￥2980
