- ￥2980
- Bioss
- bs-13018R-Cy7
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
JAK2 Rabbit pAb, Cy3 conjugated(bs-0908R-Cy3)-100ul
￥2980
lamin B1 Mouse mAb, BF647 conjugated(bsm-33040M-BF647)-100ul
￥2980
FAM70A Rabbit pAb, APC conjugated(bs-11006R-APC)-100ul
￥2980SCN5A/Nav1.5 Rabbit pAb, BF488 conjugated(bs-9445R-BF488)-100ul
￥2980QTRTD1 Rabbit pAb, BF700 conjugated(bs-19700R-BF700)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-13018R-Cy7 |
| 英文名称 | DNA Polymerase iota Rabbit pAb, Cy7 conjugated |
| 中文名称 | Cy7标记的DNA聚合酶ι/DNA pol ι抗体 |
| 英文别名 | DNA polymerase iota; Eta 2; Eta2; POLI; POLI_HUMAN; Polymerase(DNA directed) iota; RAD 30B; RAD30 homolog B; RAD30B; RAD3OB. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DNA Polymerase iota |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > DNA Polymerases |
| 亚基 | Interacts with REV1 (By similarity). Interacts with POLH. |
| 亚细胞定位 | Nucleus. Accumulates at replication forks after DNA damage. |
| 组织特异性 | Ubiquitous. Highly expressed in testis. |
| 相似性 | Belongs to the DNA polymerase type-Y family. _x000D_ Contains 1 umuC domain. |
| 功能 | Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
DNA Polymerase iota Rabbit pAb, Cy7 conjugated(bs-13018R-Cy7)-100ul
￥2980
