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- bsm-33040M-BF647
- 2025年09月30日
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100ul
| 产品编号 | bsm-33040M-BF647 |
| 英文名称 | lamin B1 Mouse mAb, BF647 conjugated |
| 中文名称 | BF647标记的核纤层蛋白B（核内参）单克隆抗体 |
| 英文别名 | LMNB1_HUMAN; Lamin-B1; LMNB1; LMN2; LMNB; LMN; ADLD; MCPH26; |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human Lamin B Protein |
| 亚型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Nucleus > Lamins Cell Biology > Apoptosis > Nucleus > Lamins Isotype/Loading Controls > Loading Controls > Lamin B1 - Nuclear Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class V > Lamins Tags & Cell Markers > Subcellular Markers > Nucleus > Nuclear Envelope |
| 亚基 | Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2. |
| 亚细胞定位 | Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side. |
| 翻译后修饰 | B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. |
| 相似性 | Belongs to the intermediate filament family. |
| 功能 | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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lamin B1 Mouse mAb, BF647 conjugated(bsm-33040M-BF647)-100ul
￥2980
