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- Bioss
- bs-10486R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-10486R-Bio |
| 英文名称 | protein C light chain Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的维生素K依赖的蛋白C轻链抗体 |
| 英文别名 | Protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; PROC; PROC1; Vitamin K dependent protein C precursor; APC; EC 3.4.21.69; PC; proC; PROC_HUMAN; Protein C(inactivator of coagulation factors Va and VIIIa); Vitamin K dependent protein C; Vitamin K-dependent protein C; Vitamin K-dependent protein C light chain. |
| 产品应用 | ELISA=1:500-5000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Vitamin K-dependent protein C light chain |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin. |
| 组织特异性 | Plasma; synthesized in the liver. |
| 翻译后修饰 | The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium._x000D_
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans._x000D_ The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains._x000D_ May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. |
| 相似性 | Belongs to the peptidase S1 family._x000D_
Contains 2 EGF-like domains._x000D_ Contains 1 Gla (gamma-carboxy-glutamate) domain._x000D_ Contains 1 peptidase S1 domain. |
| 功能 | Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:500-5000} |
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protein C light chain Rabbit pAb, Biotin conjugated(bs-10486R-Bio)-100ul
￥2980
