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- Bioss
- bs-1303R-BF488
- 2025年09月30日
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100ul
| 产品编号 | bs-1303R-BF488 |
| 英文名称 | SFRP1 Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的分泌型卷曲相关蛋白1抗体 |
| 英文别名 | Secreted frizzled related protein 1; Frizzled related protein 1; FRP 1; SARP 2; SARP-2; Secreted apoptosis related protein 2; Secreted Apoptosis-related Protein 2; Secreted frizzled related protein; Secreted Frizzled-related Protein 1; Secreted frizzled-related protein; SFRP 1; sFRP-1; SFRP1; SFRP1_HUMAN; SFRP1; FRP; FRP-1; FRP1; FrzA; SARP2. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SFRP1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Proteasome Developmental Biology > Organogenesis > Gut development > Gut specification Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Stem Cells > Signaling Pathways > Wnt > Secreted |
| 亚基 | Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. |
| 亚细胞定位 | Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. |
| 组织特异性 | Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. |
| 相似性 | Belongs to the secreted frizzled-related protein (sFRP) family. Contains 1 FZ (frizzled) domain. Contains 1 NTR domain. |
| 功能 | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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SFRP1 Rabbit pAb, BF488 conjugated(bs-1303R-BF488)-100ul
￥2980
