- ￥2980
- Bioss
- bs-13702R-BF488
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
N WASP Rabbit pAb, BF488 conjugated(bs-18981R-BF488)-100ul
￥2980
PER2 Rabbit pAb, BF647 conjugated(bs-23388R-BF647)-100ul
￥2980DCBLD2 Rabbit pAb, Cy3 conjugated(bs-5834R-Cy3)-100ul
￥2980
Beta catenin Rabbit pAb, AP conjugated(bs-23663R-AP)-100ul
￥2980
Aquaporin 4 Rabbit pAb, PerCP-Cy5.5 conjugated(bs-0634R-PerCP-Cy5.5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-13702R-BF488 |
| 英文名称 | SKAP55 Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的SKAP55蛋白抗体 |
| 英文别名 | pp55; SCAP 1; SCAP1; SKAP 1; SKAP 55; SKAP-55; Skap1; SKAP1_HUMAN; SKAP55 adaptor protein; SRC family associated phosphoprotein 1; Src family-associated phosphoprotein 1; Src kinase associated phosphoprotein 1; SRC kinase associated phosphoprotein 55 kD; Src kinase associated phosphoprotein of 55 kDa; Src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SKAP55 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Cell Type Markers > Non-CD > APC Immunology > Immunoglobulins > Receptors Signal Transduction > Adapters > Transmembrane Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Src Family |
| 亚细胞定位 | Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. |
| 组织特异性 | Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). |
| 翻译后修饰 | Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC. |
| 相似性 | Belongs to the SKAP family. _x000D_ Contains 1 PH domain. _x000D_ Contains 1 SH3 domain. |
| 功能 | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
SKAP55 Rabbit pAb, BF488 conjugated(bs-13702R-BF488)-100ul
￥2980
