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- bs-13677R-RBITC
- 2025年09月30日
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100ul
| 产品编号 | bs-13677R-RBITC |
| 英文名称 | RUSC1 Rabbit pAb, RBITC conjugated |
| 中文名称 | RBITC标记的RUSC1抗体 |
| 英文别名 | DKFZp761A1822; Nesca; New molecule containing SH3 at the carboxy terminus; RUN and SH3 domain containing 1; RUN and SH3 domain containing protein 1; RUSC 1. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RUSC1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity). |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Translocated to the nuclear envelope upon stimulation with NGF. |
| 组织特异性 | Predominantly expressed in brain. |
| 翻译后修饰 | Phosphorylated on serine residues following nuclear translocation. Polyubiquitinated; polyubiquitination involves TRAF6. |
| 相似性 | Contains 1 RUN domain. Contains 1 SH3 domain._x000D_ |
| 功能 | RUSC1 is a putative signaling adapter which may play a role in neuronal differentiation and may be involved in regulation of NGF-dependent neurite outgrowth. It seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | RUSC1 is a 902 amino acid protein that contains a RUN domain and a SH3 domain. RUSC1’s RUN domain is necessary for NGF induced nuclear redistribution. RUSC1 is a putative signaling adapter which may play a role in neuronal differentiation. RUSC1 seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. RUSC2 (RUN and SH3 domain containing 2), also known as Iporin, is a 1,516 amino acid cytoplasmic protein that is widely expressed, with highest levels in brain and testis. The RUN domain of RUSC2 is required for interaction with Rab 1A, Rab 1B and GM130. It is thought that RUSC2 may possibly function as a connector between endoplasmic reticulum (ER) derived vesicle targets triggered by the Rab 1 GTPases and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions. RUSC2 also consists of a SH3 domain, suggesting a role in protein-protein interactions. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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RUSC1 Rabbit pAb, RBITC conjugated(bs-13677R-RBITC)-100ul
￥2980
