MATH1 Rabbit pAb, BF555 conjugated(bs-3522R-BF555)-100ul

MATH1 Rabbit pAb, BF555 conjug

ated(bs-3522R-BF555)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-3522R-BF555
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-3522R-BF555
    英文名称MATH1 Rabbit pAb, BF555 conjugated
    中文名称BF555标记的肠道分化干细胞MATH-1蛋白抗体
    英文别名ATH 1; ATH1; ATOH 1; ATOH1; Atonal homolog 1; Atonal protein homolog 1; HATH 1; HATH1; Helix loop helix protein hATH 1; MATH 1; MATH1.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MATH1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH

    Neuroscience > Neurology process > Neurogenesis

    Neuroscience > Sensory System > Auditory system

    Stem Cells > Signaling Pathways > Notch > Nuclear

    亚细胞定位Nucleus.
    相似性Contains 1 basic helix-loop-helix (bHLH) domain.
    功能MATH1 protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. MATH1 is neural-specific and is switched on during differentiation into neuroectoderm.
    _x000D_ Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9.5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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