- ￥1890 - 4890
- Leading Biology
- AMR01045N
- 美国
- 2025年07月12日
- WB (Homo sapiens, Spodoptera frugiperda) IHC (Homo sapiens)
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
ULK1; ATG1; ATG1A; UNC51; Unc51.1; hATG1; ULk1
- 浓度：
Affinity purification
- 应用范围：
WB (Homo sapiens, Spodoptera frugiperda) IHC (Homo sapiens)
- 宿主：
Rabbit
- 适应物种：
Human
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 保存条件：
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- 亚型：
IgG
- 免疫原：
A synthetic phosphorylated peptide around S555 of human Phospho-ULK1-S555 (NP_003556.1).
- 规格：
50 µl/100 µl/200 µl
| 规格： | 50 µl | 产品价格： | ￥1890.0 |
|---|---|---|---|
| 规格： | 100 µl | 产品价格： | ￥3000.0 |
| 规格： | 200 µl | 产品价格： | ￥4890.0 |
Observed MW: 113KDa
细胞定位：Cytoplasm, Preautophagosomal structure, cytosol
稀释方法：WB 1:1000 - 1:2000
总结：Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.
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