- ￥2980
- Bioss
- bsm-41327M-BF350
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
PLP2 Rabbit pAb, AP conjugated(bs-12733R-AP)-100ul
￥2980
Beta tubulin Recombinant Rabbit mAb, BF405 conjugated(bsm-33034R-BF405)-100ul
￥3200
CLSTN1 Rabbit pAb, BF405 conjugated(bs-11644R-BF405)-100ul
￥2980
Angiotensinogen Rabbit pAb, APC-Cy7 conjugated(bs-20777R-APC-Cy7)-100ul
￥2980
Beta catenin Recombinant Rabbit mAb, PE-Cy5.5 conjugated(bsm-55526R-PE-Cy5.5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bsm-41327M-BF350 |
| 英文名称 | ZO-1 Mouse mAb, BF350 conjugated |
| 中文名称 | BF350标记的胞质紧密粘连蛋白1/闭锁小带蛋白1单克隆抗体 |
| 英文别名 | ZO1_HUMAN; Tight junction protein ZO-1; TJP1; ZO1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1; ZO1 tight junction protein; |
| 产品应用 | ICC/IF=1:50-200, Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human ZO-1 protein |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Tags & Cell Markers > Subcellular Markers > Plasma Membrane |
| 亚基 | Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and MYZAP. Interacts (via PDZ domain) with GJA1. |
| 亚细胞定位 | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells. |
| 组织特异性 | The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. |
| 翻译后修饰 | Phosphorylated. Dephosphorylated by PTPRJ. |
| 相似性 | Belongs to the MAGUK family._x000D_
Contains 1 guanylate kinase-like domain._x000D_ Contains 3 PDZ (DHR) domains._x000D_ Contains 1 SH3 domain._x000D_ Contains 1 ZU5 domain. |
| 功能 | The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {Flow-Cyt} | {1μg/Test} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
ZO-1 Mouse mAb, BF350 conjugated(bsm-41327M-BF350)-100ul
￥2980
