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- bs-0224R-BF488
- 2025年09月30日
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100ul
| 产品编号 | bs-0224R-BF488 |
| 英文名称 | NCoR1 Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的核受体辅助抑制因子1抗体 |
| 英文别名 | RIP13; Rxrip13; hCIT529I10; hN CoR; hNCoR; KIAA1047; MGC104216; N CoR; N Cor/SMRT corepressor Rip13; N CoR1; NCOR 1; NCoR; NCOR1; Nuclear receptor co repressor 1; Nuclear receptor corepressor 1; Retinoid X receptor interacting protein 13; thyroid hormone and retinoic acid receptor associated corepressor 1; thyroid hormone-and retinoic acid receptor-associated corepressor 1; TRAC 1; TRAC1; Nuclear Receptor Corepressor NCoR; NCOR1_MOUSE. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse NC0R1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains. SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is faciliated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and KDM3A. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with HDAC9 (via its catalytic domain). Interacts with CBFA2T3 and HEXIM1. Interacts (via the RRFD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. |
| 亚细胞定位 | Nucleus |
| 翻译后修饰 | Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation. |
| 相似性 | Belongs to the N-CoR nuclear receptor corepressors family._x000D_
Contains 2 SANT domains._x000D_ |
| 功能 | Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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NCoR1 Rabbit pAb, BF488 conjugated(bs-0224R-BF488)-100ul
￥2980
