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- bs-11365R-BF488
- 2025年09月30日
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100ul
| 产品编号 | bs-11365R-BF488 |
| 英文名称 | SV2B Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的突触泡蛋白2B抗体 |
| 英文别名 | Synaptic vesicle protein 2B; SV2B_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SV2B |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurotransmission > Calcium Signaling > Calcium Pump Neuroscience > Neurotransmission > Receptors / Channels > More Ion Channels |
| 亚基 | Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity). |
| 亚细胞定位 | Cytoplasmic vesicle, secretory vesicle. Synaptic vesicle membrane; Multi-pass membrane protein. |
| 翻译后修饰 | N-glycosylated (By similarity). The N-terminal cytoplasmic domain is phosphorylated by CK1 (By similarity)._x000D_ |
| 相似性 | Belongs to the major facilitator superfamily. |
| 功能 | SV2s (Synaptic Vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. While SV2A is expressed ubiquitously throughout the brain, SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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SV2B Rabbit pAb, BF488 conjugated(bs-11365R-BF488)-100ul
￥2980
