CD13 Rabbit pAb, PE conjugated(bs-1383R-PE)-100ul

CD13 Rabbit pAb, PE conjugated

(bs-1383R-PE)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-1383R-PE
  • 2025年10月15日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      产品信息以Bioss网站为准

    • 规格：

      100ul

    产品编号bs-1383R-PE
    英文名称CD13 Rabbit pAb, PE conjugated
    中文名称PE标记的CD13抗体
    英文别名ANPEN; Aminopeptidase N; Alanyl aminopeptidase; Alanyl membrane aminopeptidase; Aminopeptidase M; Aminopeptidase N; ANPEP; APN; CD 13; CD13 antigen; gp150; hAPN; Lap 1; Lap1; Alanyl(membrane) aminopeptidase; AMPN_HUMAN; AP M; AP N; AP-M; AP-N; LAP 1; LAP1; PEPN; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p150.
    中文别名氨肽酶N;
    产品应用Flow-Cyt=1µg/Test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CD13
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Immunology > Cell Type Markers > CD > Myeloid Cells

    Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus

    Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage

    Stem Cells > Hematopoietic Progenitors > Myeloid > Dendritic Cell Lineage

    Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage

    Stem Cells > Mesenchymal Stem Cells > Surface Molecules

    亚基Homodimer. Interacts with the S1 domain of HCoV-229E spike protein.
    亚细胞定位Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol (Potential). Note=A soluble form has also been detected.
    组织特异性Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
    翻译后修饰Sulfated.
    N- and O-glycosylated.
    May undergo proteolysis and give rise to a soluble form
    相似性Belongs to the peptidase M1 family.
    功能Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]

     

    应用推荐稀释比例
    {Flow-Cyt}{1µg/Test}
    {IF}{1:100-500}

     

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