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- bs-11564R-PE-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-11564R-PE-Cy7 |
| 英文名称 | Gli2 Rabbit pAb, PE-Cy7 conjugated |
| 中文名称 | PE-Cy7标记的转录因子Gli2抗体 |
| 英文别名 | Gli 2; Gli-2; GLI family zinc finger 2; GLI kruppel family member 2; GLI Kruppel family member GLI2; GLI2; GLI2_HUMAN; Oncogene GLI2; Tax helper protein 2; Tax helper protein; Tax responsive element 2 holding protein; Tax responsive element 25 bp sequence binding protein; THP 2; THP; THP2; Zinc finger protein GLI2. |
| 产品应用 | Flow-Cyt=3ug/test, ICC/IF=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Gli2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Neuroscience > Neurology process > Neural Signal Transduction Stem Cells > Signaling Pathways > Hedgehog > Nuclear |
| 亚基 | Interaction with ZIC |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Phosphorylated in vitro by ULK3. |
| 相似性 | Belongs to the GLI C2H2-type zinc-finger protein family. _x000D_ Contains 5 C2H2-type zinc fingers. |
| 功能 | FunctionActs as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal._x000D_ |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | It has long been known that the overexpression of either Wnt-1 or the GLI proteins results in cancer; however, the molecular basis for this transformation was poorly understood. The Wnt-1 and GLI proteins have now been placed in a signaling cascade downstream of the mammalian homologs of the Drosophila hedgehog and patched proteins. The Drosophila segment polarity gene hedgehog (hh) encodes a secreted protein that appears to function in embryonic and imaginal disc patterning. The ptc gene, also identified as a Drosophila segment polarity gene, encodes the transmembrane protein patched, the expression of which is precisely regulated during embryonic development. Hedgehog has been shown to enhance the expression of the Wnt family of proteins through a signaling cascade involving the GLI transcription factors, while patched functions as a repressor opposing the effects of hedgehog. Mutations in the ptc gene, which result in unregulated hedgehog signaling, have been correlated with the most common type of cancer, basal cell carcinoma, which affects 750,000 individuals annually in the United States alone. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3ug/test} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
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Gli2 Rabbit pAb, PE-Cy7 conjugated(bs-11564R-PE-Cy7)-100ul
￥2980
