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- Bioss
- bs-15449R-BF555
- 2025年09月30日
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100ul
| 产品编号 | bs-15449R-BF555 |
| 英文名称 | HEG1 Rabbit pAb, BF555 conjugated |
| 中文名称 | BF555标记的HEG同源蛋白1抗体 |
| 英文别名 | HEG; HEG1; HEG1_HUMAN; KIAA1237; MST112; MSTP112; HEG homolog 1; Protein HEG homolog 1. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HEG1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Growth Factors Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Developmental Biology > Organogenesis > Angiogenesis and vasculogenesis Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Tight Junctions Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins |
| 亚基 | Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction. Isoform 2: Secreted (Potential). |
| 相似性 | Contains 2 EGF-like domains. |
| 功能 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HEG1 (HEG homolog 1) is also known as HEG and is a 1,381 amino acid protein that exists as two alternatively spliced isoforms, one of which is a single-pass membrane protein and the other of which is secreted. HEG1, which is expressed in endothelial cells and smooth muscle cells of heart tissue, contains two EGF-like domains that play a role in calcium-binding events which may regulate concentric heart growth. The gene encoding HEG1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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HEG1 Rabbit pAb, BF555 conjugated(bs-15449R-BF555)-100ul
￥2980
