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human Fibrinogen Rabbit pAb, F

ITC conjugated(bs-1240R-FITC)-100ul
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  • ￥2980
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  • bs-1240R-FITC
  • 2025年10月15日
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      100ul

    产品编号bs-1240R-FITC
    英文名称human Fibrinogen Rabbit pAb, FITC conjugated
    中文名称FITC标记的人纤维蛋白原抗体
    英文别名FGA; FGA protein; FGB; FGG; Fib2; Fibrin alpha chain; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405; FIBA_HUMAN.
    产品应用Flow-Cyt=1μg /test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原Fibrinogen from human plasma
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Atherosclerosis > Thrombosis

    Cardiovascular > Blood > Coagulation > Common

    Cardiovascular > Blood > Platelets

    Metabolism > Types of disease > Metabolic disorders

    亚细胞定位Secreted.
    组织特异性Plasma.
    翻译后修饰The alpha chain is not glycosylated.
    Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylation sites are present in the extracellular medium.
    相似性Contains 1 fibrinogen C-terminal domain.
    功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

     

    应用推荐稀释比例
    {Flow-Cyt}{1μg /test}
    {IF}{1:100-500}

     

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    图标文献和实验
    该产品被引用文献

    [IF={{ 5.9 }}] {Chen, Jiang, et al. "Effect of the Duration of UV Irradiation on the Anticoagulant Properties of Titanium Dioxide Films." ACS Applied Materials & Interfaces(2015).} {Other} {="Human"}

    [IF={{ 4.29 }}] {Chen, Jiang, et al. "The effect of full/partial UV-irradiation of TiO2 films on altering the behavior of fibrinogen and platelets." Colloids and Surfaces B: Biointerfaces (2014).} {Other} {="Human"}

    相关实验

    • The OP9-DL1 System: Generation of T-Lymphocytes from Embryonic or Hematopoietic Stem Cells In Vitro

      . In vitro human T cell development directed by notch-ligand interactions. Methods Mol. Biol. 430: 135142.[Medline] Bunting, K.D., ed. 2008. Hematopoietic stem cell protocols . Humana Press, Clifton, NJ. de Pooter, R. and Zúñiga-Pflücker, J.C

    • （共享）免疫单词缩写及翻译

      rabbit serum albumin 兔血清白蛋白 R-Sc Reed-Sternberg's cell 瑞-司氏细胞 Z/R Reinheit Zahl 光密度比值 SAV small agranular vesicle 无颗粒小泡 SBA soybean agglutinin 大豆凝集素 SC secretory component 分泌成份 SCV small clear vesicle 清亮小泡 SDS sodium

    • Jackson ImmunoResearch 二抗选用指南

      （ min X….Mouse, Rat Sr Prot ）。 以下是圆括号中所使用的一些简称： Bov = Bovine Ck = Chicken Gt = Goat GP = Guinea Pig Sy Hms = Syrian Hamster Hrs = Horse Hu = Human Ms = Mouse Rb = Rabbit Shp

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    human Fibrinogen Rabbit pAb, FITC conjugated(bs-1240R-FITC)-100ul
    ￥2980