MED12/Trap230 Rabbit pAb, AP conjugated(bs-18763R-AP)-100ul产品图

MED12/Trap230 Rabbit pAb, AP c

onjugated(bs-18763R-AP)-100ul
收藏
  • ￥2980
  • Bioss已认证
  • bs-18763R-AP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
avatar
北京博奥森生物技术有限公司
品牌商
10 年钻石会员

  • 企业认证

    点击 QQ 联系

    • 相关产品推荐更多 >

    万千商家帮你免费找货

    0 人在求购买到急需产品

    相关阅读

    香烟烟雾如何加速声带纤维化？CD44-透明质酸轴是关键通路Takara 秋促来袭，提取+反转录+定量套装仅 1200 元五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图
    • 详细信息
    • 文献和实验
    • 技术资料
    • 应用范围：

      产品信息以Bioss网站为准

    • 规格：

      100ul

    产品编号bs-18763R-AP
    英文名称MED12/Trap230 Rabbit pAb, AP conjugated
    中文名称AP标记的甲状腺激素受体相关蛋白复合物230抗体
    英文别名Activator recruited cofactor 240 kDa component; Activator-recruited cofactor 240 kDa component; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; CAGH45; HOPA; KIAA0192; MED12; MED12_HUMAN; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; Mediator of RNA polymerase II transcription subunit 12; Mediator of RNA polymerase II transcription subunit 12; OPA containing protein; OPA-containing protein; OPA-containing protein; Thyroid hormone receptor associated protein complex 230 kDa component; Thyroid hormone receptor-associated protein complex 230 kDa component; Thyroid hormone receptor-associated protein complex 230 kDa component; TNRC11; Trap230; Trinucleotide repeat containing gene 11 protein; Trinucleotide repeat-containing gene 11 protein; Trinucleotide repeat-containing gene 11 protein.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MED12/Trap230
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Mediator Complex

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    Epigenetics and Nuclear Signaling > Transcription > RNA polymerase

    亚基Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3.
    亚细胞定位Nucleus.
    组织特异性Ubiquitous.
    相似性Belongs to the Mediator complex subunit 12 family.
    功能Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

    风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    相关实验

    • Western 杂交

      SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts.    ・        

    • Developing Genetically Engineered Mouse Models to Study Tumor Suppression

      transgene but not its random or imprinted X inactivation. Proc. Natl. Acad. Sci. U.S.A. 103:9958‐9963.    Clarke, A.R., Maandag, E.R., van Roon, M., van der Lugt, N.M., van der Valk

    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    MED12/Trap230
    ￥1500
    上海博尔森生物科技有限公司
    2025年06月30日询价
    MED12/Trap230 Rabbit Polyclonal Antibody 抗体，orb185550，Biorbyt
    ￥3159
    武汉博欧特生物科技有限公司
    2026年07月21日询价
    MED12/Trap230甲状腺激素受体相关蛋白复合物230抗体
    ￥1880
    上海晶风生物科技有限公司
    2025年06月13日询价
    TRAP1 Rabbit pAb
    ￥1024
    攸碧艾（上海）生物技术有限公司
    2026年06月13日询价
    TRAP1 Rabbit pAb
    ￥1150
    武汉爱博泰克生物科技有限公司
    2026年06月18日询价
    MED12/Trap230 Rabbit pAb, AP conjugated(bs-18763R-AP)-100ul
    ￥2980