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- bs-5240R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-5240R-Bio |
| 英文名称 | phospho-Caspase 6 (Ser257) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化半胱胺酸蛋白酶蛋白6抗体 |
| 英文别名 | Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN. |
| 产品应用 | ELISA=1:5000-10000, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human Caspase 6 around the phosphorylation site of Ser257 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Apoptosis Markers > Caspases Cancer > Cell Death > Apoptosis > Metabolism Cancer > Invasion/microenvironment > Apoptosis > Caspases Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease |
| 亚基 | Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. |
| 亚细胞定位 | Cytoplasm. |
| 翻译后修饰 | Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. |
| 相似性 | Belongs to the peptidase C14A family. |
| 功能 | Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
| {Flow-Cyt} | {1ug/test} |
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phospho-Caspase 6 (Ser257) Rabbit pAb, Biotin conjugated(bs-5240R-Bio)-100ul
￥2980
